Thrombin Generation and Atherothrombosis: What Does the Evidence Indicate?

16 , 17 , 18 Mendelian randomization studies as well as case–control studies show highly significant risk associations between different coagulation proteins and atherosclerosis as well as atherothrombotic complications.

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Interestingly, only subjects with severe CAD had a significantly increased ETP (average 130% of normal), whereas the increase in low‐grade and moderate CAD did not reach statistical significance (averages 123% and 121%, respectively). 39 Carcaillon et al did not find an association between history of CAD and increased TG, but they did find an association with acute ischemic coronary disease and high TG, more apparent in women than in men. 47 While ETP and peak were elevated, the lag time was slightly delayed in patients with a history of MI as compared to those without such history; the inhibitory effect of thrombomodulin, indicative of APC resistance, was not significantly different in these 2 subgroups.

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