Prolonged High-Dose Bivalirudin Infusion Reduces Major Bleeding Without Increasing Stent Thrombosis in Patients Undergoing Primary Percutaneous Coronary Intervention: Novel Insights From an Updated Meta-Analysis.

32 , 33 The “prognostically more relevant” TIMI major bleeding (fatal bleeding, intracranial bleeding, or overt bleeding with drop of hemoglobin ≥5 g/dL) was also reported in HORIZONS‐AMI, BRAVE‐4, and EUROMAX, but failed to reach statistical significance in the BRAVE‐4 and EUROMAX trials.

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