Analytical Validation and Clinical Qualification of a New Immunohistochemical Assay for Androgen Receptor Splice Variant-7 Protein Expression in Metastatic Castration-resistant Prostate Cancer.

The increase in nuclear AR-V7 expression between HSPC and after AA or EZ treatment was highly significant ( p < 0.0001), as was the increase in nuclear AR-V7 between pre and post AA or EZ ( p = 0.007) treatment biopsies.

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The present study demonstrates a significant trend towards poorer outcome among patients with increased AR-V7 protein expression, in keeping with previous reports for nonmatched cohorts [26] , [27] , [28] , and points to an association between AR-V7 expression and poor prognosis. 5 Conclusions This is the first longitudinal report demonstrating increasing AR-V7 protein expression in matched same-patient biopsies before and after endocrine treatment from patients with emerging resistance.

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