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Characteristics and Trends in Hypnotics Consumption in the Largest Health Care System in Israel.

Sleep Disord · 2016 · PMC5021873 · PMID 27660727

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a strong trendno p-value reported
Third, there is a strong trend to switch from monotherapy of benzodiazepines in 2000 to combined hypnotic medication treatment in 2010, along with reduction in benzodiazepine usage and increase in Z drugs usage.

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