The enhanced atorvastatin hepatotoxicity in diabetic rats was partly attributed to the upregulated hepatic Cyp3a and SLCO1B1.

Sci Rep · 2016 · PMC5021965 · PMID 27624558

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showed a trendno p-value reported

C max (194.09 ± 24.85 ng/mL in PB rats versus 277.01 ± 71.22 ng/mL in rats) of atorvastatin in PB rats showed a trend to increase, although no significance was observed.

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