Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization.

We have found nominally significant associations with total dairy and milk in every population [BPRHS (P = 0.031 for dairy and P = 0.037 for milk), GOLDN (P = (2.8 × 10 −3 ) for dairy and P = 1.1 × 10 −3 for milk), PREDIMED (P = 1.9 × 10 −6 for dairy and P = 4.0 × 10 −6 for milk) and WHI (P = 3.4 × 10 −66 for dairy and P = 1.2 × 10 −65 for milk] despite differences in allele frequency and amount of milk consumed.

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The interaction by sex was borderline significant for milk (P = 0.055).

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