Preliminary evidence for association of genetic variants in pri-miR-34b/c and abnormal miR-34c expression with attention deficit and hyperactivity disorder.

Transl Psychiatry · 2016 · PMC5022091 · PMID 27576168

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

showed a trendP =0.058so close (0.05 < p ≤ 0.1)

MiR-34b-3p also showed a trend towards increased expression in ADHD when compared with controls ( P =0.058; Exp(B)=2,70; CI=0.89–8.20) and no differences were observed for miR-34b-5p or miR-34c-5p.

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a trend towards significanceno p-value reported

In addition, our findings regarding miR-34b and mirR-34c expression levels also require replication in a larger and independent cohort as the limited sample size considered may have led to imprecise estimates of the magnitude of the miRNA expression differences and could have prevented us from detecting significant differences for miR-34b, which only displayed a trend towards significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.