Meditation and vacation effects have an impact on disease-associated molecular phenotypes.

The analysis of variance of group differences in change scores was marginally significant ( P <0.08; Supplementary Table S9 ).

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Highly significant gene expression changes were detected across all groups (the ‘vacation effect') that could accurately predict (96% accuracy) between baseline and post-intervention states and were characterized by improved regulation of stress response, immune function and amyloid beta (Aβ) metabolism.

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Regular meditators showed a trend toward increased telomerase activity compared with randomized women, who showed increased plasma Aβ42/Aβ40 ratios and tumor necrosis factor alpha (TNF-α) levels.

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