An investigation of the association of genetic susceptibility risk with somatic mutation burden in breast cancer.

We observed a significant trend ( P =2.28 × 10 −3 , Figure 1 right panel) in that the strength of association of the individual SNPs with TSMC (measured by the regression coefficient) tended to be larger for those with larger reported odds ratio of association with breast cancer risk, but this trend was largely influenced by SNP rs11814448 in DNAJC1 ( P =0.37 when excluding SNP rs11814448).

also in 9,775 other papers

In particular, a highly significant inverse association was observed with respect to the germline risk variant defined by the SNP rs2588809 in the DNA-repair gene RAD51B .

also in 132,142 other papers