Metabolomics reveals dose effects of low-dose chronic exposure to uranium in rats: identification of candidate biomarkers in urine samples.

We observed that the discrimination between control and contaminated rats for this low dose started as a strong trend from 3 months of contamination onward (model 14, Table 2 , panel B; R2Y = 81 %, Q2Y = 58 %) and increased with contamination duration after 6 months (model 15, Table 2 , panel B; R2Y = 82 % and Q2Y = 64 %), and after 9 months (model 16, Table 2 , panel B; R2Y = 84 % and Q2Y = 70 %).

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