Intron Length Coevolution across Mammalian Genomes.

Coexpressed genes showed marginally significant evidence ( P = 0.07) of coevolution of the lengths of intergenic regions, but the extent of coevolution for intergenic lengths was significantly less than for intron lengths (e.g., partial Pearson correlation coefficients of genes belonging to the same GTEx coexpression clusters were significantly higher in the case of introns than intergenic regions; P = 7.4 × 10 − 8 ).

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Given that there was overall evidence of coevolution of members of the same protein complex and an excess of nominally significant complexes over the null expectation we applied the q -value method ( Storey and Tibshirani 2003 ) to investigate properties of the collection of statistical tests applied to protein complexes.

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