Furthermore, when looking at the weight distribution of individuals recruited to participate in clinical trials for Crohn’s disease, there has been a clear trend in increasing weight over the past two decades, from a minimum mean BMI of 20.8 kg/m 2 in 1992, to a maximum mean BMI of 27.0 in 2001, and a weakly positive linear trend ( r 2 = 0.14) of increasing BMI among study participants throughout this period of time[ 16 ].
1
—
—