Induced conformational change in human IL-4 upon binding of a signal-neutralizing DARPin.

Proteins · 2015 · PMC5029753 · PMID 25900776

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quite significantno p-value reported

The results of the study presented here provides an interesting example in which a very stable high‐affinity DARPin binds to a cytokine with a well characterized structure, inducing a quite significant change in the conformation of the IL‐4 C α‐helix and the CD loop region.

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