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Dose-dense and less dose-intense Total Therapy 5 for gene expression profiling-defined high-risk multiple myeloma.

Blood Cancer J · 2016 · PMC5030385 · PMID 27471869

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a strong trendno p-value reported
While the intended timely sequencing of TT5 treatment segments was accomplished at acceptable toxicities (off study rate for toxicities, 12%), clinical outcomes were similar in TT5 and predecessor trials TT3a and TT3b, with a strong trend for inferiority for complete response durations despite comparable CR kinetics.

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