Quantitative proteomics of rat livers shows that unrestricted feeding is stressful for proteostasis with implications on life span.

In contrast, the level of IGF-ALS, a protein that stabilizes IGF-I in the serum, was found to be reduced in RES (although results did not reach statistical significance, in some RES samples it was undetectable) and increased in CU to a level lower but similar to that of AL (Table 2 , Supplementary Table 1 ).

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