Sitagliptin improves glycaemic excursion after a meal or after an oral glucose load in Japanese subjects with impaired glucose tolerance.

Sitagliptin treatment for 8 weeks reduced MTT plasma glucagon (Figure 2 C, Table 2 ); the LS mean change from baseline plasma glucagon total AUC 0–2 h associated with the 25 mg dose was significant compared with placebo (p = 0.003), while the LS mean change in plasma glucagon total AUC 0–2 h associated with the 50 mg dose, compared with placebo, did not reach statistical significance.

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