Alterations in Systemic Extracellular Heme and Hemopexin Are Associated With Adverse Clinical Outcomes in Ugandan Children With Severe Malaria.

Children who died of infection within either 48 hours or 14 days had an approximately 3-fold higher ratio of heme to hpx at admission than children who survived these periods, but the ratios of heme to hpx at admission did not reach statistical significance in predicting mortality at 48 hours (median, 0.126 among 14 who died vs 0.040 among 165 who survived; P = .232; Figure 4 A ) or day 14 (median, 0.130 among 16 who died vs 0.039 among 163 who survived; P = .139; Figure 4 B ).

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