Enhanced cardiac TBC1D10C expression lowers heart rate and enhances exercise capacity and survival.

HR was also reduced in this second line (line 2); although the reduction did not reach statistical significance (HR: WT: 407 ± 12 beats/min, n = 15; TG: 384 ± 13 beats/min, n = 15; n.s.), a similar CO was observed in WT and TG mice despite significantly higher EF (WT: 54.1 ± 2.3%, n = 15; TG: 60.7 ± 2.8%, n = 15; P < 0.05) ( Supplemental Fig. 1c ).

also in 111,027 other papers