Barely Significant
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GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation.

Nat Commun · 2016 · PMC5036163 · PMID 27653144

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showed a trendno p-value reported
Mice given the lower dose of rGDF11 (0.1 mg kg −1 ) also showed a trend of decreased trabecular bone volume, although it was not statistically significant ( P =0.078).

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