Quantitative EEG parameters correlate with the progression of human prion diseases.

Worsening in MRC Scale score correlated significantly with the decrease in the main background frequency on FR (r=0.62, p=1.5×10 −3 ) but showed a trend, in all the other electrode groups (p<0.05).

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Results The comparison between control participants (n=29) and symptomatic patients (sIPD and sCJD; n=44) showed highly significant differences in the main background frequency, the θ power and the α/θ power ratio ( figure 2 , table 2 and see online supplementary table S1). supplementary table jnnp-2016-313501supp_table.pdf As expected, the main frequency was lower in patients than in controls, whereas they had increased power in the θ band and decreased α/θ power ratio.

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