Consolidation chemotherapy improves progression-free survival in stage III small-cell lung cancer following concurrent chemoradiotherapy: a retrospective study.

17 Bryne et al demonstrated that six cycles of cyclophosphamide, vincristine, and methotrexate (CVM) consolidation after induction therapy showed a trend toward inferior OS (median OS: 14.1 months vs 19.2 months, P =0.05). 18 In addition to the four studies previously mentioned, other studies also explored the role of CCT in SCLC; however, those studies randomized both limited and extensive stages and came to different conclusions.

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