Birth weight in relation to health and disease in later life: an umbrella review of systematic reviews and meta-analyses.

Both meta-analyses looking at low (<2500 g) versus high (≥4000 g) BW and those examining per 1 SD increase in BW showed highly significant summary effects and small between-study heterogeneity.

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Forty-seven of 78 associations presented a nominally significant summary effect and 21 associations remained statistically significant at P < 1 × 10 −6 .

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