Barely Significant
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A unified statistical model of protein multiple sequence alignment integrating direct coupling and insertions.

Biophys Physicobiol · 2016 · PMC5042171 · PMID 27924257

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a negative trendno p-value reported
Second, while the correlation between internal energy and entropy differences is linear and positive for the J -only system (CC=0.96) as was the case with the globin, that for the J + K system of the V-set domain shows only a negative trend for the entire range of Δ U (CC=−0.92).

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