Evaluation of optimum conditions for pachyman encapsulated in poly(d,l-lactic acid) nanospheres by response surface methodology and results of a related in vitro study.

Using multiple regression analysis on the experimental data, the predicted response Y can be obtained by the following second-order polynomial equation: (3) Y = + 53.62 + 5.45 X 1 − 2.47 X 2 + 1.47 X 3 + 4.70 X 1 X 2 + 2.40 X 1 X 3 − 3.45 X 2 X 3 − 7.69 X 1 2 + 1.42 X 2 2 − 4.24 X 3 2 As shown in Table 2 , ANOVA of the linear regression model demonstrated that the model was highly significant ( P > F , P <0.0001).

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With regard to the combined influence exhibited by both the F68 concentration (w/v) and the PLA-to-drug ratio (w/w) ( Figure 3C and D ), their reciprocal interaction on EE showed a significant trend of first increase and then decrease, which implied strong interaction between these two variables.

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