Impaired ADAMTS9 secretion: A potential mechanism for eye defects in Peters Plus Syndrome.

Although the anterior chamber volume was reduced in most Adamts9 del/ + eyes, comparison with wild-type chamber volumes did not reach statistical significance owing to the considerable variability of ASD and the presence of buphthalmos (enlarged eye) in at least one Adamts9 del/ + eye ( Fig. 1e ).

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In addition to Peters anomaly, corneal invasion by lens epithelium, lens capsule deposition in the corneal stroma, as well as increased keratocyte density are together likely to be significant contributors to corneal opacity.

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