Impact of PI3K/AKT/mTOR pathway activation on the prognosis of patients with head and neck squamous cell carcinomas.

Specifically, we found that patients harboring laryngeal tumors with S6 phosphorylation on either Ser235/236 or Ser240/244 exhibited a significantly improved disease-specific survival (Log-rank test, P = 0.002 and P < 0.001, Figure 3A and 3B ), whereas differences did not reach statistical significance in the subgroups of hypopharyngeal and oropharyngeal carcinomas (Figure 3C – 3F ).

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