Although the presence of Cx43 in EVs did not show a statistically significant difference in terms of therapeutic effect of dox, in the majority of the evaluated parameters there is a clear trend for EV Cx43+ to present a better anti-tumoural performance, compared to EV Cx43− .
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Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin.
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