Exposure to inorganic arsenic can lead to gut microbe perturbations and hepatocellular carcinoma.

Acta Pharm Sin B · 2016 · PMC5045549 · PMID 27709011

Europe PMC DOI

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hugely significantno p-value reported

27 showed that arsenic exposure in utero of mice in tandem with high folate administration caused a hugely significant change in CpG island methylations.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.