Gastrointestinal Safety of Aspirin for a High-Dose, Multiple-Day Treatment Regimen: A Meta-Analysis of Three Randomized Controlled Trials.

Drugs R D · 2016 · PMC5045830 · PMID 27449765

Europe PMC DOI

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did not reach statistical significanceno p-value reported

Gastrointestinal AEs were more common in subjects treated with aspirin (7.4 %) than with placebo (5.4 %), and although this difference did not reach statistical significance, a trend towards increased risk was observed with aspirin use [OR: 1.41 (95 % CI 0.78, 2.54); RD: 2.00 (95 % CI −1.35, 5.35)].

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a trend towards significanceno p-value reported

However, there is a very wide CI associated with this estimate (0.6, 44), suggesting a substantial level of variability in the data due to the low number of cases (sparse data scenario), but also a trend towards significance due to the large right shift of the CI.

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