Analysis of 23andMe antidepressant efficacy survey data: implication of circadian rhythm and neuroplasticity in bupropion response.

23 In the recent ENIGMA analysis of 1728 MDD patients and 7199 controls, MDD (especially recurrent MDD and patients with earlier age of onset (AOO⩽21 years)) had significantly lower hippocampal volumes, although patients with earlier AOO also showed a trend toward smaller amygdala volumes. 24 In our analysis the T allele was associated specifically with better bupropion response.

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