ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors.

EMBO Mol Med · 2016 · PMC5048365 · PMID 27596438

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Altogether, an inverse correlation was observed between ZEB1 and MITF levels in BRAF V600 ‐mutated melanoma at the intra‐tumoral level, and this ZEB1 high /MITF low profile showed a trend toward intrinsic resistance to MAPKi.

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