Methylation of SOCS3 is inversely associated with metabolic syndrome in an epigenome-wide association study of obesity.

Remarkably, we observed highly significant association between the methylation state at cg18181703 and the MetS status in our large cohort ( P = 4.01 × 10 −7 ) ( Table 3 ), suggesting the epigenetic status at this site of gene SOCS3 is strongly inversely associated with the presence of MetS.

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While this site was the most statistically significant, 4 other CpG sites in the same CpG island were also nominally significant (data not shown) and consistent with the finding in cg18181703 , all 4 sites the methylation status was negatively correlated with obesity.

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