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Pyrophosphate Stimulates Differentiation, Matrix Gene Expression and Alkaline Phosphatase Activity in Osteoblasts.

PLoS One · 2016 · PMC5049792 · PMID 27701417

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Alkaline phosphatase expression increased 1.5–3 fold over control for 100μM (P = 0.016) and 0.1μM treatment groups, though this difference failed to reach statistical significance for the 0.1μM treatment group.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.