Vaginal progesterone decreases preterm birth ≤ 34 weeks of gestation in women with a singleton pregnancy and a short cervix: an updated meta-analysis including data from the OPPTIMUM study.

Ultrasound Obstet Gynecol · 2016 · PMC5053235 · PMID 27444208

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a clear trendno p-value reported

This hypothetical scenario is unlikely, given that the OPPTIMUM study 44 showed a clear trend towards reduction in the risk of preterm birth ≤ 34 weeks of gestation (23%) and neonatal death or serious neonatal morbidity (∼42%) associated with the use of vaginal progesterone.

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