Proteolysis of plasminogen activator inhibitor-1 by Yersinia pestis remodulates the host environment to promote virulence.

Although the differences in the levels of active plasmin in the airspaces did not reach statistical significance on comparison of Y. pestis ∆pla infection of wild‐type mice and PAI‐1 −/− mice infected with 10 4 CFUs, the effects of PAI‐1 and Pla on active plasmin generation were clear on comparison of Y. pestis ∆pla dose‐matched samples in wild‐type and PAI‐1 −/− mice (Fig. 7 B).

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