Dopamine D1/D5 receptor signaling regulates synaptic cooperation and competition in hippocampal CA1 pyramidal neurons via sustained ERK1/2 activation.

Hippocampus · 2016 · PMC5054950 · PMID 26194339

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However, with the application of 5 μM U0126 from 60 minutes onwards, the maintenance of potentiation was affected; the potentiation was only marginally significant by 120 minutes ( P < 0.05) and gradually decayed back to baseline becoming not significantly different from the baseline 145 minutes onwards ( P > 0.05, Fig. 4 a, n = 7).

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