Barely Significant
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Navigable rivers facilitated the spread and recurrence of plague in pre-industrial Europe.

Sci Rep · 2016 · PMC5056511 · PMID 27721393

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a clear trendno p-value reported
There is a clear trend that the width of river holds a positive association with the total number of plague outbreak, while the city-river distance holds a negative association with the plague outbreak.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.