Common variants in IL-17A/IL-17RA axis contribute to predisposition to and progression of congestive heart failure.

Medicine (Baltimore) · 2016 · PMC5058840 · PMID 27399111

Europe PMC DOI

hedged sentences

0.0050

closest p · 0.1× alpha

0.0620

boldest claim

The sentences

highly significantP = 0.005actually significant

borderline significanceP = 0.050actually significant

After adjustment for age, sex, smoking status, diabetes, hypertension, and dyslipidemia, these associations were still highly significant for ischemic heart failure (OR = 0.74; 95% CI = 0.60–0.91, P = 0.005) and retained borderline significance for nonischemic heart failure (OR = 0.80; 95% CI = 0.61–1.00, P = 0.050). 3.3.

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failed to reach statistical significanceP = 0.062so close (0.05 < p ≤ 0.1)

Overall, the difference in circulating IL-17A level between GG (median, 5.30 pg/mL; interquartile range [IQR], 0–8.76 pg/mL) and GA genotypes (median, 0 pg/mL; IQR, 0–7.13 pg/mL) failed to reach statistical significance ( P = 0.062).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.