Effect of BRCA germline mutations on breast cancer prognosis: A systematic review and meta-analysis.

Medicine (Baltimore) · 2016 · PMC5059054 · PMID 27749552

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closest p · 1.2× alpha

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showed a trendP -value = 0.06so close (0.05 < p ≤ 0.1)

Taking into account data derived from all studies, BRCA mutation carriers showed a trend for worse OS (HR 1.27, 95% CI: 0.99–1.64; P -value = 0.06) and a higher risk of death from breast cancer (HR 1.44, 95% CI: 1.05–1.97; P -value = 0.02), and of distant metastasis (HR 1.82, 95% CI: 1.05–3.16; P -value = 0.03) than control group. 3.7.

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