Circulating histones are major mediators of systemic inflammation and cellular injury in patients with acute liver failure.

Cell Death Dis · 2016 · PMC5059889 · PMID 27685635

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showed a trendP <0.05actually significant

These cytokines in CLD patients showed a trend toward higher levels than in the healthy controls, but only IL-6, IL-8, and IL-10 levels attained a statistical difference (all P <0.05).

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