Barely Significant
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Brief report: intraarticular sprifermin not only increases cartilage thickness, but also reduces cartilage loss: location-independent post hoc analysis using magnetic resonance imaging.

Arthritis Rheumatol · 2015 · PMC5061102 · PMID 26138203

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Differences in thinning and thickening of the cartilage, subregions of the cartilage, and OVs did not reach statistical significance between the sprifermin‐ and placebo‐treated patients in these dose groups.

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