Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1.

Nucleic Acids Res · 2016 · PMC5063001 · PMID 27587584

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closest p

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quite significantno p-value reported

Likewise, differences between the previous structure of chromomycin–DNA(TTGGCCAA) ( 17 ) and our structure of MTM SA–Trp–DNA complex are quite significant: atomic positional differences of DNA backbones reach ∼4 Å and angle differences between the respective bases are as large as ∼20–30°.

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