As shown in Figure 5 , in BSA-fed BMDM from WT mice, adiponectin treatment decreased TNF-α mRNA expression significantly, as expected, and the macrophages from SIRT1KO mice also showed decreased TNF-α mRNA expression with adiponectin, although the change did not reach statistical significance.
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Adiponectin treatment attenuates inflammatory response during early sepsis in obese mice.
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