Circadian rest-activity rhythms during benzodiazepine tapering covered by melatonin versus placebo add-on: data derived from a randomized clinical trial.

When comparing the median value at follow-up for IV (0.81 in the PRM group versus 1.01 in the placebo group) there was a borderline significant difference ( p = 0.06) with the lowest value (indicating the least diurnal rhythm fragmentation) in the melatonin group, but for RA there was no difference between intervention groups (0.83 in both groups).

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Activity counts were generally higher after benzodiazepine dose reduction compared with pre tapering, but differences did not reach statistical significance.

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