A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model.

J Inherit Metab Dis · 2016 · PMC5065612 · PMID 27469509

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Interim echocardiography 1 month after cross-over showed a trend toward improved cardiac function in Idh2R140Q-veh/AGI mice, with decreases in LVM/BW and increases in EF (not significant; Fig. 4b, c ).

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