Phase 1 Study of Safety, Tolerability, and Pharmacokinetics of PTC299, an Inhibitor of Stress-Regulated Protein Translation.

Increases in mean C max and AUC 0–24 values were generally dose‐proportional (Table 2 ); although the increases in mean AUC 0‐24 values tended to be greater than dose‐proportional through a dose of 1.00 mg/kg and then less than dose‐proportional between doses of 1.00 and 3.00 mg/kg, these differences across groups in dose‐proportionality did not reach statistical significance (ANOVA following log transformation of PK parameters).

also in 111,027 other papers