Feasibility of investigating differential proteomic expression in depression: implications for biomarker development in mood disorders.

Of the 272 proteins measured and analyzed from 288 samples (141 controls, 52 Unipolar, 49 Bipolar II, 46 Bipolar I), 73 showed nominally significant difference among the 4 compared groups at an uncorrected significance level ( P <0.05. see bold font in Supplementary Table 1 ); 6 of those proteins showed statistically significant differences after Bonferroni correction ( P< 0.05/272=1.84e−04) (growth differentiation factor 15 (GDF-15), hemopexin (HPX), hepsin (HPN), matrix metalloproteinase-7 (MMP-7), retinol-binding protein 4 (RBP-4) and transthyretin (TTR)).

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