Rapid effects of deep brain stimulation reactivation on symptoms and neuroendocrine parameters in obsessive-compulsive disorder.

Neuroendocrine changes DBS ON → DBS OFF The mean TSH plasma levels decreased by 61% ( P =0.003) from DBS ON to DBS OFF ( Table 1 and Figure 3a ), whereas the mean prolactin levels decreased by 59% ( P =0.003; Figure 3b ) and the median GH levels were 360% lower during OFF relative to active stimulation, although the difference failed to reach statistical significance.

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