Genes upregulated in archival comparison of MDD versus controls also showed significant over-representation of CREB and NRF2 TFBMs, and genes upregulated in cancer patients with high levels of depressive symptoms showed significant over-representation of CREB/ATF TFBMs and marginally significant ( P =0.059) over-representation of NRF2 TFBMs.
Analysis of the archival MDD versus control comparison also indicated highly significant signals for all of the other pathways analyzed; however, these indications were not corroborated in the cancer/depressive symptoms' sample.
Results also indicated nominally significant and unanticipated under-representations of NF-κB and EGR2 response elements in promoters of genes upregulated in association with MDD, although these latter two findings would not attain significance under Bonferroni correction for multiple testing across the nine TFBMs analyzed.