Impact of gonadotropin-releasing hormone antagonist addition on pregnancy rates in gonadotropin-stimulated intrauterine insemination cycles.

Prospective data have shown that premature LH surge occurs in almost 23% of COS cycles (95% CI 22–43%),[ 16 ] which appears quite significant and can interfere with the optimal timing of the insemination.[ 10 12 ] LH surge can be effectively prevented by administering a gonadotropin-releasing hormone (GnRH) agonist or GnRH antagonist.[ 12 17 18 ] Use of GnRH agonist is not recommended in IUI cycles because of prolonged administration of injections prior to and during stimulation to achieve complete downregulation of GnRH receptors, risk of excessive follicular stimulation, and higher cost and inconvenience to the patient.

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